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Natalizumab is used to treat multiple sclerosis patients

10.1002/ajmg.a.10847 Am

Because the G of reaction mainly relates to enthalpy, entropy and temperature, the difference in the structure of Cu catalytic site will not cause a significant difference in the overall G of catalytic reaction, which is supported by the calculated results in Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 82.Lesseur C, Gilbert-Diamond D, Andrew A.S, Ekstrom R.M, Li Z, Kelsey K.T, Marsit C.J, Karagas M.R

5-(3-bromo-d5-propylidene)-5H-dibenzo[a,d]cycloheptene (from EXAMPLE 5) and 3-fluoro-pentadeutero-azetidine, deuterochloride salt (from EXAMPLE 6) are combined using the procedure in EXAMPLE 4 to make 1-(3-Dibenzo[a,d]cyclohepten-5-ylidene-d5-propyl)-3-fluoro-pentadeutero-azetidine